Particularly, to make laboratory determinations clinically usable and to ensure that the measurement variability does not gain the upper hand obscuring the clinical information supplied by the test results, it is essential to estimate the measurement uncertainty (MU) of results produced by procedures intended to measure biological measurands, and to verify that the estimated MU is within objectively defined analytical performance specifications (APS). The main scope of laboratory medicine is to provide useful information for correct clinical decision-making in order to significantly contribute to the quality of health care. ConclusionsĪPS for MU of clinical samples derived in this study are essential to objectively evaluate the reliability of results provided by medical laboratories. For C-reactive protein, allocated to the model 3, a desirable MU of 3.76% was defined. Plasma potassium, sodium, chloride, total calcium, alanine aminotransferase, creatinine, urea, and total bilirubin were allocated to the model 2 and the corresponding desirable APS were 1.96, 0.27, 0.49, 0.91, 4.65, 2.20, 7.05, and 10.5%, respectively. Resultsīlood total hemoglobin, plasma glucose, blood glycated hemoglobin, and serum 25-hydroxyvitamin D3 were allocated to the model 1 and the corresponding desirable APS were 2.80, 2.00, 3.00, and 10.0%, respectively. Both minimum and desirable levels of quality of APS for standard MU of clinical samples were defined by using information obtained from available studies. We allocated a group of 13 measurands selected among the most commonly laboratory requested tests to each of the three Milan models on the basis of their biological and clinical characteristics. Using these models appropriately, we present here a proposal for defining APS for standard MU for some common biochemical measurands. The 2014 Milan Strategic Conference have proposed models to objectively derive APS based on: (a) the effect of analytical performance on clinical outcome (b) biological variation components and (3) the state of the art of the measurement, defined as the highest level of analytical performance technically achievable. These user designed simulations combine both text based instructions and the simulation into a single distributable file.Definition and fullfillment of analytical performance specifications (APS) for measurement uncertainty (MU) allow to make laboratory determinations clinically usable. Users can expand upon the original lab set using ChemLab's LabWizard development tools, thus allowing for curriculum specific lab simulation development by educators. Users step-through the actual lab procedure while interacting with animated equipment in a way that is similar to the real lab experience.ĬhemLab comes with a range of pre-designed lab experiments for general chemistry at the high school and college level. Commonly used lab equipment and procedures are used to simulate the steps involved in performing an experiment. Model ChemLab is a unique product incorporating both an interactive simulation and a lab notebook workspace with separate areas for theory, procedures and student observations. It has continued to be developed with extensive input from educators interested in the possible application of computer simulations for classroom and distance learning. ChemLab originated from academic work in computer simulation and software design at McMaster University.
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